There is growing literature on how gut microbiota might influence anxiety , depression and cognition via the microbiota- gut- brain axis. Probiotic supplemantation with Lactobacillus rhamnosus decreased anxiety like and depressive like behaviours.A range of potential mechanism by which the gut microbiota affects central nervous system function have been proposed , These include altered microbial composition,immune inactivation,gut hormone response, and through production of neuro active substances , Probiotic Lactobacillus and bifidobacterium significantly have good effects on anxiety , postpartum depression